To gain further insight into the molecular mechanism of svtRNA1-2–mediated NRS, several modified svtRNA1-2 molecules were transfected into the human breast cancer cell line MCF-7, and the expression level of nascent ERBB4 RNA was assessed by RT–qPCR, 24 h post-transfection (Fig 7F). Here, ERBB4 is linked to breast carcinoma.