NAMPT promotes cancer progression both through its enzymatic activity, which increases intracellular NAD(H) levels (Kennedy et al, 2016), and by being secreted (extracellular NAMPT, eNAMPT) and binding extracellularly to cell surface receptors such as the C-C chemokine receptor type 5 (CCR5) (Grolla et al, 2016; Jiao et al, 2018; Torretta et al, 2020; Ratnayake et al, 2021). The gene discussed is CCR5; the disease is cancer.