The aberrant expression of matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of metalloproteinase-3 (TIMP-3) is potentially associated with metastasis in several carcinomas such as NPC [156], cervical cancer [157], breast cancer [158], lung cancer [159], and colon cancer [160]. This evidence concerns the gene TIMP3 and nasopharyngeal carcinoma.