APP and Alzheimer disease: For analysis of body weight, wecombined our groups (Young and Aged cohorts) and as such it is possible that theselarge group sizes enabled a significant difference between genotypes from an earlierage than previously reported [37, 56].Nevertheless, weight loss in AD mice is not unexpected as weight loss is well knownto progress with disease progression in human patients with AD [83, 84] and in individuals at risk for AD (A+T+),potentially downstream of Abeta deposition [85].