For example, studies have shown that within rodent DIO models, there are decreases in Pomc (Proopiomelanocortin) expression, which codes for an important appetite regulatory enzyme that gives rise to a wide range of satiety hormones and has been implicated in obesity [13], and this is related to increased DNA methylation of the Pomc promoter [14]. The gene discussed is POMC; the disease is obesity due to melanocortin 4 receptor deficiency.