The Hepatitis B Research Network (HBRN) adult cohort study enrolled a racially diverse CHB cohort from 20 US centers and 1 center in Toronto, Canada.8 Earlier analyses of the baseline characteristics of the cohort found significant differences in the presumed mode of infection, HBV genotype, hepatitis B e antigen (HBeAg) status, HBV DNA levels, and alanine aminotransferase (ALT) levels across racial groups, and among African American or Black participants, significant differences between those born in the US, East Africa, and West Africa.9 This evidence concerns the gene GPT and hepatitis B virus infection.