Perhaps the most intriguing finding within the study of IgAV skin is that the KIR transcripts detected with the KIR Activating Subgroup 1 probe (KIR3DS1, KIR2DS1, KIR2DS2, and KIR2DS4) are the most highly differentially depressed skin transcripts in patients with IgAV who develop nephritis. Here, KIR2DS4 is linked to nephritis.