However, the methylation of uc.160 + related CpG islands can promote the proapoptotic effect of RING1 and YY1-binding protein (RYBP) targets and forkhead box P2 (FOXP2) to regulate tumor suppressor genes and proto-oncogenes by regulating and editing pri-miR-376 clusters, thus leading to a better prognosis of glioma patients [57]. This evidence concerns the gene FOXP2 and central nervous system cancer.