Uc.134 can inhibit the development of HCC by inhibiting Cullin 4A (CUL4A) ubiquitination of Large Tumor Suppressor Kinase 1 (LATS1) and increasing YAPS127 phosphorylation, thereby activating the Hippo kinase signal [43]. The gene discussed is CUL4A; the disease is hepatocellular carcinoma.