The overexpression of uc.457 can inhibit the proliferation of P19 cells in a time-dependent manner and reduce the expression of genes related to myocardial maturation such as Histone Cell Cycle Regulator (HIRA), Natriuretic Peptide A (NPPA), Troponin T2, Cardiac Type (CTnT) and Myocyte Enhancer Factor 2C (Mef2c), which demonstrates aberrant uc.457 expression can induce coronary heart disease [25]. This evidence concerns the gene HIRA and coronary artery disorder.