CD4 and melanoma: Consistently, melanoma patients had an obviously higher level of infiltration of anti-tumor immune components, such as CD8 T cells, M1 macrophage, and activated memory CD4 T cells (Figure 3G), whereas some pro-tumor immune components, like M2 macrophage, resting mast cells, and resting memory CD4 T cells, showed a significantly higher infiltration in patients from the Cluster B (Figure 3G).