SSRIDDs, including Coffin–Siris syndrome (CSS) and Nicolaides–Baraitser syndrome (NCBRS), stem from variants in genes of the Brahma-Related Gene-1 Associated Factor (BAF) complex, also known as the mammalian SWI/SNF complex (Hoyer et al. 2012; Santen et al. 2012; Tsurusaki et al. 2012; Van Houdt et al. 2012; Tsurusaki et al. 2014; Hempel et al. 2016; Bramswig et al. 2017; Bogershausen and Wollnik 2018; Vasileiou et al. 2018; Gazdagh et al. 2019; Machol et al. 2019; Zawerton et al. 2019). Here, BANF1 is linked to Coffin-Siris syndrome.