Given the neurological and musculoskeletal clinical findings in SSRIDD, and CdLS patients (Schrier Vergano et al. 2013; Bogershausen and Wollnik 2018; Kline et al. 2018; Avagliano et al. 2020; Selicorni et al. 2021; Vasko and Schrier Vergano 2022), we assessed startle-induced sensorimotor integration for RNAi of brm, osa, Snr1, SMC1, SMC3, and vtd relative to their control genotype. Here, SMC3 is linked to Cornelia de Lange syndrome.