Among these 11 modules, genes in the blue module were significantly enriched in the steroid biosynthesis (GO:0016126), biological process and steroid biosynthesis (Ko00100), mitogen-activated protein kinase (MAPK) signaling (Ko04011), and pathogenic Escherichia coli infection (Ko05130) pathways (Fig. 2B and C). The gene discussed is WNK2; the disease is escherichia coli infection.