CCL15, an important gene reported to be upregulated in the intestinal epithelium of patients with IBD (27) and known to play a critical role in neutrophil infiltration (neutrophil chemotaxis) (28), was significantly upregulated in VEH/SIV RMs (FC = 9.5), while its related natural antisense lncRNA RP11-104J23.1 was downregulated (FC = 3.6). The gene discussed is CCL15; the disease is irritable bowel syndrome.