When inducing polymicrobial sepsis by injecting 250 μL of cecal slurry (CS) intraperitoneally, WT and msuPAR1-OE mice experienced more severe AKI compared with uPAR-KO mice deficient in suPAR (Figure 3, A–C, and Supplemental Figure 1) within 24 hours of sepsis induction. This evidence concerns the gene PLAUR and acute kidney injury.