We found that A. cantoniensis Hance may enhance the activity of protein kinases, promote the growth of neuronal cells body, and regulate hepatitis related signaling pathways (PI3K-AKt, MAPK, IL-2/IL-6/IL-17 signaling pathway and so on), which can serve as a reference in hepatitis E treatment. This evidence concerns the gene AKT1 and hepatitis A virus infection.