The enrichment results of KEGG pathway show that the key target genes of A. cantoniensis Hance in treating hepatitis E were significantly enriched in the several signal pathways, including pathways in cancer, PI3K-AKt signaling pathway, EGFR tyrosine kinase inhibitor resistance, Hepatitis C pathway, Thyroid hormone signaling pathway, and etc., besides, the MAPK signaling pathway, p53 signaling pathway, B cell receptor signaling pathway, Hepatitis B, T cell receptor signaling pathway, TNF signaling pathway and so on, were also included (p < 0.05). This evidence concerns the gene TP53 and cancer.