Radiomics is the high-throughput voxel-based quantitative analysis of medical images.44 Analysis of radiomic features can provide an alternative, noninvasive method that utilizes automatic data-characterization algorithms to extract features from radiographic images.45,46 IDH-mutant versus IDH-wildtype lower grade gliomas have shown differences in radiomic descriptors extracted from T2-weighted images. Here, IDH2 is linked to central nervous system cancer.