Among them, TYMS, KIF2C, UBE2C, and HJURP are associated with unfavorable prognosis in hepatocellular carcinoma, possibly due to the malignant growth of cells (Ieta et al., 2007; Chen et al., 2018; Wei et al., 2021; Wang et al., 2022). The gene discussed is TYMS; the disease is hepatocellular carcinoma.