P4HA3 is located upstream of the PI3K/AKT signaling pathway, and type VI α6 collagen (COL6A6) interacts with P4HA3 to inhibit pituitary adenoma (PA) growth and metastasis by blocking the PI3K/AKT signaling pathway (Long et al., 2019). This evidence concerns the gene COL6A6 and pituitary gland adenoma.