CD4 and cancer: Furthermore, as seen in the correlation heat map, P4HA3 was closely associated with a variety of immune cells such as CD8+ T cells, CD4+ T cells, B cells, neutrophils, myeloid dendritic cells, macrophages, cancer-associated fibroblast (CAF), endothelial cells, and Hematopoietic stem cells in pan-cancer (Figure 8A).