L1CAM and Agenesis of corpus callosum: For example, in a 25 WG fetus with a highly variable fetal prognosis (corpus callosum agenesis and ventriculomegaly without any other malformations) (Yeh et al., 2018; Bernardes da Cunha et al., 2021), ES evidenced a causative maternally inherited hemizygous L1CAM missense variant with a poor neurodevelopmental prognosis (MIM:304100), leading to ToP after the molecular result.