All nine patients carried a rare missense deleterious variant in LMNA except two (patient 9-EDMD-and 11-L-CMD-) whose carried deletions (p.Glu31ArgfsTer65 and c.1488_1488+9del, respectively) (Tables 1–3). The gene discussed is LMNA; the disease is Emery-Dreifuss muscular dystrophy.