Of note, Kiss1 downregulation was also seen in BPH/5 females when compared to sex- and age-matched C57 controls (Figure 5A, p = 0.0002), while rWAT Kiss1 and Kiss1r were not different between adult BPH/5 and A-C57 males (Supplementary Figure 2, p > 0.05). Here, KISS1R is linked to benign prostatic hyperplasia.