While mice globally lacking either functional Kiss1 or Kiss1r have impaired pubertal development (i.e., hypogonadotropic hypogonadism), the BPH/5 mouse may be a suitable additional model to further study the crosstalk between reproductive hormones, adipose tissue kisspeptin dysregulation and adiposity (de Roux et al., 2003; Funes et al., 2003; Seminara et al., 2003; Tassigny et al., 2007; Tolson et al., 2019). The gene discussed is KISS1R; the disease is benign prostatic hyperplasia.