Furthermore, studies using Kiss1r KO mice have shown that impaired kisspeptin signaling leads to increased body weight, adiposity, and hyperleptinemia in adult female mice, along with decreased energy expenditure and impaired glucose tolerance (Tolson et al., 2014; Tolson et al., 2016; Tolson et al., 2019). The gene discussed is KISS1; the disease is Impaired glucose tolerance.