AKT1 and cancer: Many of the top pathways in both tissues are broadly related to growth and proliferation (Mitogen-activated protein kinase (MAPK), cancer, phosphatidylinositol 3-kinase- RAC (Rho family)-alpha serine/threonine-protein kinase (PI3k-Akt)) and specifically glucose metabolism (insulin, central carbon metabolism in cancer, Hypoxia-Inducible Factor-1 (HIF-1) signaling).