NOTCH3 and CADASIL: However, there is conflicting evidence surrounding how Notch3 function affects pericytes depending on the model investigated–Notch3−/− mice (Henshall et al., 2015), diabetic Notch3−/− mice (Liu et al., 2018), zebrafish (Wang et al., 2014), or in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (Dziewulska and Lewandowska, 2012; Del Gaudio et al., 2022).