Indeed, Bordenave et al. (2020a) have shown that the daily treatment of rats with established PAH (induced either by MCT injection or SU5416-CH) with compounds that suppress CXCR4 activity was able to reduce PAH disease severity, attenuate right ventricular hypertrophy, prevent remodelling of the pulmonary vasculature, and decrease pericyte coverage of arterioles. This evidence concerns the gene CXCR4 and pulmonary arterial hypertension.