However, selective cleaving of polysialylation moieties using endoneuraminidase N inhibited the antidepressant efficacy of fluoxetine in a chronic unpredictable stress model for depression-like behaviors, likely by disrupting the interaction of PSA-NCAM with the D2 dopamine receptor in the medial PFC (Castillo-Gómez et al., 2008, 2011; Wainwright et al., 2016). Here, NCAM1 is linked to major depressive disorder.