There are various functional autoantibodies in patients with systemic sclerosis secreted by dysregulated B cells that target endothelial cells, intercellular adhesion molecule 1 (ICAM-1), endothelin type A receptor (ETAR), angiotensin II type I receptor (AT1R) and platelet-derived growth factor receptor (PDGFR). This evidence concerns the gene ICAM1 and systemic sclerosis.