The presence of MELF pattern showed significant decreases from 283/mm2 to 176/mm2 medians of CD8+ in total areas (Mann-Whitney-U-test, p = 0.035), which was even more pronounced in close subregions with a decrease from 385/mm2 to 247/mm2 (Mann-Whitney-U test, p = 0.016). This evidence concerns the gene CD8A and Lafora disease.