The expression levels of phospholipid scramblase 1 (PLSCR1), heme binding protein 1 (HEBP1), structural maintenance of chromosomes 4 (SMC4), and RuvB like AAA ATPase 1 (RUVBL1) genes were shown to be reversed by candidate compounds for psoriasis using the RORUCI values. The gene discussed is HEBP1; the disease is psoriasis.