FUT4 and neoplasm: Meanwhile, it also takes up higher percentages in peritumoral region rather than tumor site, which plays a crucial role by impairing antitumor immunity (31).Tumor-associated neutrophils have two types of subpopulations: anti-tumoral(N1) and pro-tumoral(N2) and CD15 + neutrophils are inclined to present a pro-tumoral phenotype in peritumoral areas among tumor-associated neutrophils, promoting tumor initiation and promotion (32) and leading to shorter survival (33, 34).