Nevertheless, the status of SMAD4 did not significantly differ by sex (P > 0.9999), Tumor Node Metastasis stage (P > 0.9999), T stage (P = 0.8576), N stage (P = 0.9329), tumor differentiation (P = 0.5694), surgical margin (P > 0.9999), vascular invasion (P = 0.2983), adjuvant chemotherapy (P = 0.8368), or adjuvant radiotherapy (P > 0.9999). This evidence concerns the gene SMAD4 and neoplasm.