The E3-ubiquitin ligase complex that primarily participates in NRF2 degradation depends on cullin-3 (Cul3), a core component and scaffold protein of the E3 ligase complex, which is one of the most increased in SS-patients, together with other cullins (cullin-5 and cullin-1) (15). The gene discussed is CUL3; the disease is synovial sarcoma.