Some proteins of these genes have already been associated with pathophysiological processes in the kidney: in tubulointerstitial fibrosis (c-MYC, PTEN, STAT3, HIF-1α, PT53) (58–62); podocyte injury (EGFR, PT53, CTNNB1, CREB1) (60, 63–65); epithelial-mesenchymal transition (PTEN) (66); and glomerulosclerosis (DICER1, IL1β) (67, 68). The gene discussed is STAT3; the disease is fibrosis.