Summarizing the recent findings about HS and CD, there appears to be an association between the two: (1) the genetic predispositions factors associated with increased risk of HS in IBD (SULT1B1 and SULT1E1), (2) the same environmental factor predisposition with increased risk of shooting both HS and CD (i.e., smoking), and, (3) the good response to treatment with anti-TNF-α in HS (as well as in dermatological EIM). This evidence concerns the gene SULT1E1 and inflammatory bowel disease.