Moreover, the demonstration that in interstitial lung disease-idiopathic pulmonary fibrosis (ILD-IPF), IL-8 and its receptor CXCR1 are highly expressed by mesenchymal progenitor cells (MPCs), which are the cellular originators of IPF fibroblasts, is of clinical significance. The gene discussed is CXCL8; the disease is idiopathic pulmonary fibrosis.