Of particular interest, the injection of human MSCs obtained from synovial tissue of patients with osteoarthritis (OA) into the joint cavity of collagen-induced arthritis (CIA) in DBA/1J mice model was associated with a decrease in TNF-α, IFN-γ, and interleukin-17A (IL-17A), while IL-10 production increased. This evidence concerns the gene IL17A and osteoarthritis.