The demonstration that IL-8 plays an important role in neuropathic pain (following nerve injury) (70), and the observation that an inhibitor of IL-8-CXCR1/2 interaction improved neuropathic pain (71), suggest that IL-8 may indeed play a role in chronic neuropathic pain that affects 17–21% of patients with RA (72). Here, CXCL8 is linked to rheumatoid arthritis.