In contrast, when studying gene expression in whole blood-derived cells, patients with RA stabilized under etanercept (a fusion protein produced by recombinant DNA that fuses the TNF receptor to the constant end of the IgG1 antibody) showed an increased expression of the IL-8 gene, as well as under infliximab therapy (a DNA-derived chimeric monoclonal antibody working by binding to and neutralizing TNFα) (98). The gene discussed is CXCL8; the disease is rheumatoid arthritis.