In fact, the IL-17A/IL-17Ra axis has been demonstrated to be critical in murine fibrosis models (77), and most importantly, it was demonstrated, in vitro, that IL-17A-stimulated human fibroblasts proliferation can be suppressed by inhibitors of Janus Kinase 2 (JAK2) or JAK1-3, while myofibroblast transdifferentiation is sensitive to JAK2 inhibition (78). The gene discussed is JAK2; the disease is fibrosis.