The Fmr1 global knockout (KO) mouse generated over three decades ago (The Dutch-Belgian Fragile X Consortium, 1994) exhibits a variety of neurological and behavioral phenotypes, including audiogenic seizures, hypersensitivity to auditory stimuli, hyperactivity, repetitive behaviors, and memory deficits (Pietropaolo et al., 2011; Kramvis et al., 2013; Li et al., 2020), mimicking symptoms in FXS patients (Wisniewski et al., 1991; Musumeci et al., 1999; Rais et al., 2018). Here, FMR1 is linked to fragile X syndrome.