RARA and acute promyelocytic leukemia: From a mutational perspective, APL is genetically uncomplex (The Cancer Genome Atlas Research Network, 2013) and characterized by the presence of fusion genes arising from reciprocal translocations involving RARA, predominantly with the PML gene [t(15;17)(q22;q21), 98% of cases] that subsequently encodes the oncogenic PML-RARα fusion protein.