EZH2 and cancer: Recent research has demonstrated that EZH2 also performs canonical as well as potentially opposing non-canonical roles in multiple types of cancer (Wang and Wang, 2020; Anwar et al., 2021; Huang et al., 2021; Wang et al., 2022a; Wang et al., 2022b; Poplineau et al., 2022), and our results indicate that this is also true in the context of myeloid differentiation.