From a mutational perspective, APL is genetically uncomplex (The Cancer Genome Atlas Research Network, 2013) and characterized by the presence of fusion genes arising from reciprocal translocations involving RARA, predominantly with the PML gene [t(15;17)(q22;q21), 98% of cases] that subsequently encodes the oncogenic PML-RARα fusion protein. This evidence concerns the gene PML and acute promyelocytic leukemia.