KDM1A and acute promyelocytic leukemia: While one of the principal reasons underpinning the success of this approach is that LSD1 plays a critical role in the regulation of expression of genes involved in the differentiation of hematopoietic stem cells (Kerenyi et al., 2013), it is noteworthy that a non-canonical scaffolding role for LSD1 has also been identified in APL (Ravasio et al., 2020).