There is emerging evidence of G9A and GLP playing roles in cancer stemness, metastasis and drug resistance (Haebe et al., 2021; Nachiyappan et al., 2022), as well as having a specific roles in AML (Goyama et al., 2010; Son et al., 2012; Lehnertz et al., 2014). The gene discussed is EHMT1; the disease is acute myeloid leukemia.