Studies to classify DLBCL into different subgroups also revealed clearly that LOF mutations in the DDX3X gene were enriched in subtypes that carry c-MYC translocations over other subcategories of DLBCL, which provides another hint for a link between these two proteins in lymphomagenesis (48, 86, 138). Here, DDX3X is linked to diffuse large B-cell lymphoma.