In these mouse models, the observations made in human GC B cells were not entirely reproduced and c-MYC overexpressing cells that had lost DDX3X did not expand and only those lymphomas were obtained that did not delete Ddx3x, indicating that loss of DDX3 activity is incompatible with c-Myc induced lymphomagenesis in mice (47) (Figure 6). This evidence concerns the gene DDX3X and lymphoma.