DDX3 being an essential gene, at least one of the two paralogs is indispensable for cell survival (154, 155), particularly in a B cell lymphoma context as shown by the aberrant DDX3Y expression in human lymphoma with a DDX3X LOF; and by the DDX3Y overexpression in murine lymphoma cells with a Ddx3x KO (47, 48). Here, DDX3Y is linked to B-cell non-Hodgkin lymphoma.