MYC and lymphoma: The c-MYC gene is a paradigmatic example for these genetic accidents, as two of the hallmarks of GC-derived lymphomas, notably BL, are the activation of c-MYC by chromosomal translocation of its coding region to the regulatory elements of the Ig locus, and the occurrence of mutations withing the MYC coding region that stabilizes the protein by counteracting its ubiquitination and proteasome-mediated degradation (75, 86–88).