The genes identified in all four subgroups were RFTN1, C1orf103, FKBP1B, COL25A1, NPDC1, B3GNT1, FOXN3, RNASEH2C, TLE1, and PHF17. Of these, RFTN1, COL25A1, TLE1, and RNASEH2C have been found to have sex differences in methylation in leukocytes (22), which are known to impact tumor maintenance (23) and be regulated by sex hormones (24, 25). This evidence concerns the gene COL25A1 and neoplasm.