HAVCR2 and neoplasm: In the second model: TNM-stage, tumor budding, and Tim3 expression in CT were entered and showed that TNM-stage (HR= 3.504, 95% CI= 2.030-6.047, P< 0.001) and Tim3 expression in CT (HR= 1.799, 95% CI= 1.057-3.065, P= 0.031) were remained in the equation as independent prognostic factors for shorten OS (Table 6).