HAVCR2 and neoplasm: When the patients were stratified by tumor side, we observed that high CD8 expression in IM in right-sided CRCs was significantly associated with favorable OS (HR= 0.288, 95% CI= 0.083-0.995, P= 0.049) while Tim3 in the left-sided CRCs was significantly associated with poorer OS (HR= 2.064, 95% CI= 1.063-4.007, P= 0.032) (Table 7).