Our results demonstrated that the expression of these two markers had a synergistic effect in predicting OS, though it was not significant (P= 0.228 for CT, HR, CI, P= 0.276 for IM) The best OS was observed in patients with high PD-1 and Tim3 expression in IM but low PD-1 and Tim3 expression in the CT implying that their synergistic effect depends on the tumor region (more details in Figure 3). Here, HAVCR2 is linked to neoplasm.