In the first model: T-stage, lymph node involvement, M-stage, tumor budding and Tim3 expression in CT were entered and showed that lymph node involvement (HR= 2.705, 95% CI= 1.576-4.641, P< 0.001), M-stage (HR= 5.949, 95% CI= 2.863-12.361, P< 0.001), and Tim3 expression in CT (HR= 1.732, 95% CI= 1.005-2.985, P= 0.048) were independent prognostic factors for OS. This evidence concerns the gene HAVCR2 and neoplasm.