The data showed that tongue tumors (PD-1 blockade sensitive) contained a higher percentage of CD8+ T cells (6.8% - 12.7%) and a lower percentage of CD19+ B cells (1.95% - 6.65%) in comparison with subcutaneous tumors (PD-1 blockade resistant) which contained from 1.23% - 8.04% CD8+ T cells and from 3.31% - 12.8% CD19+ B cells (Figure 1A). Here, CD19 is linked to tongue neoplasm.