AFP and Encephalopathy: According to the log-rank test, more advanced BCLC stage (A), more advanced Child–Pugh class (B), higher MELD score (C), higher serum AFP level (D), worse ECOG performance status (E), presence of ascites, history of encephalopathy, greater number of tumors (F), larger tumor size (G), and portal vein invasion (H) were reliable predictors of unfavorable OS (P < 0.001).