AFP and hepatocellular carcinoma: Multivariate analysis model 1 (variables: BCLC stage, MELD score, and serum AFP) showed that BCLC stage D (HR, 4.282; P < 0.001), MELD score ≥10 (HR, 1.484; P < 0.001), and serum AFP level ≥1,000 ng/mL (HR, 1.506; P < 0.001) were associated with worse survival outcomes in untreated patients with HCC (Table 3).