KRAS and neoplasm: Also, metastatic lesions more than 4 (p = 0.001) bilobar distribution of the metastatic lesions (p = 0.0001), borderline resectable (p = 0.039) as well as an unresectable disease at (p = 0.0001), elevated CEA levels more than 5 ng/ml (p = 0.016), and non-surgical LDT (p = 0001) were associated with poor OS (refer Table 3) Age, site of primary, size of tumour >5 cm, KRAS mutational status, synchronous or metachronous liver metastasis, neo-adjuvant or pre-procedural conversion chemotherapy, and T and N stage of disease did not affect OS.