bulgaricus OLL1073R-1 (EPS-R1) induced an increase in CCR6+ CD8+T cells and production of IFN-γ in Peyer’s patches, accompanied by the expression of a large number of immune response genes, maintained T cell function, and improved the tumor microenvironment, enhancing the antitumor effects of anti-CTLA-4 or anti-PD-1 monoclonal antibodies against CCL20-expressing tumors. This evidence concerns the gene CTLA4 and neoplasm.