Secreted factors such as the CXC chemokines, TGF-β, IGF, epidermal growth factors (EGF), fibroblast growth factors (FGF), HGF, IL6, IL8, IL10 and IL11 have been reported to support the creation of a drug-resistance tumor microenvironment (52–55). The gene discussed is TGFB1; the disease is neoplasm.