Under hypoxic conditions, HCC cells can acquire CAF properties by the influence of cytokines and TGF-β which leads to an increase in the expression of FAP and α-SMA (16, 17), generates mesenchymal cells that resemble fibroblasts, and subsequently contributes to chronic tissue fibrosis and cancer progression (18). This evidence concerns the gene TGFB1 and hepatocellular carcinoma.