Contradictory, there are studies demonstrating the use of transgenic mice that selectively target α-SMA positive myofibroblasts resulted in increased tumor invasion and reduced animal survival (63, 116) This is likely due to myofibroblast/CAF that expresses α-SMA plays an important role in secreting extracellular matrix and generating mechanical tension, targeting α-SMA could result in both tumor promoting and inhibiting. The gene discussed is ACTA1; the disease is neoplasm.