As we can see, the macrophage-expressed VSIG4 in lymph node was higher than that in ccRCC tumor and adjacent normal kidney (Figure 5C), whereas the epithelium-expressed TGFBI and P4HB in ccRCC tumor were higher than those in adjacent normal kidney (Figures 5D, E). The gene discussed is P4HB; the disease is nonpapillary renal cell carcinoma.