While SF3B1 and XPO1 mutations were strong independent prognostic factors in both U-CLL and M-CLL, TP53, BIRC3 and EGR2 alterations predicted outcome only in U-CLL patients and NOTCH1 and NFKBIE in only M-CLL patients (34). Here, TP53 is linked to B-cell chronic lymphocytic leukemia.