The most studied tumor-associated antigen targets for CAR-T cells in GBM include interleukin-13 receptor alpha 2 (IL-13Rα2), EGFRvIII, and human epidermal growth factor receptor 2 (HER2) – molecules that can be expressed by GSCs (7, 8, 41). The gene discussed is IL13RA2; the disease is glioblastoma.