Mutational analysis revealed that several tumor suppressors such as tumor protein P53 (TP53) and Breast cancer susceptibility gene 1 (BRCA1) -associated protein 1 (BAP1) were mutated at a higher frequency in high CRRS HCC patients, illustrating that cuproptosis related signatures are helpful in predicting prognosis and guiding the treatment of HCC patients (133). Here, BAP1 is linked to hepatocellular carcinoma.