TP53 and neoplasm: Mutational analysis revealed that several tumor suppressors such as tumor protein P53 (TP53) and Breast cancer susceptibility gene 1 (BRCA1) -associated protein 1 (BAP1) were mutated at a higher frequency in high CRRS HCC patients, illustrating that cuproptosis related signatures are helpful in predicting prognosis and guiding the treatment of HCC patients (133).