When we took the CHB group as the control group and the HCC group as the case group, the results of the univariate analysis (Supplementary Table 5) showed that MSH6-rs1042821 (AA), MSH3-rs1428030 (CC), MSH3-rs1805355 (AA), MSH3-rs181747 (CC) and MSH6-rs1042821(AA) were risk factors. The gene discussed is MSH6; the disease is hepatocellular carcinoma.