The risk genotype TT/TA of MSH2-rs1981928 and the risk genotype GG of MSH3-rs40139 were correlated with the occurrence of the HCC when exposed alone (P=0.025, OR=1.726 and P=0.002, OR=2.355), and the two genotypes were also correlated with the occurrence of the HCC when exposed together (P=0.047, OR=1.744). The gene discussed is MSH3; the disease is hepatocellular carcinoma.