We then used univariate Cox regression and Least Absolute Shrinkage Selection Operator (LASSO) regression analyses to screen three prognostic CRGs in breast cancer patients, including PSME2, MAPK10, and EIF4EBP1. Based on these three genes, we constructed a centrosome-related prognostic model and centrosome-related signature score (CRSS) for breast cancer patients. The gene discussed is EIF4EBP1; the disease is breast cancer.