Similarly, KEGG analysis revealed that upregulated centrosome-related DEGs in tumor tissues were mainly enriched in cell cycle, cellular senescence and p53 signaling pathway (Figure 1E; Supplementary Table 2), while downregulated CRGs were enriched in signaling pathways like sphingomyelin and prolactin (Figure S1B; Supplementary Table 2). The gene discussed is TP53; the disease is neoplasm.