Multiple signaling pathways involved in pancreatic cancer tumorigenesis - Ras-ERK pathway (5), multiple genes/proteins, such as NOP14 (6), DCLK1 (7), interleukin-22/interleukin-22 receptor (8), FoxQ1 (9), CHIP (10) and microRNAs (11) - were recently found to play an important role in migration and invasion of pancreatic cancer cells. Here, IL22RA1 is linked to familial pancreatic carcinoma.