Interestingly, Selumetinib, a selective MEK1 inhibitor, was reported to enhance the antitumor activity of everolimusa against renal cell carcinoma by decreasing p-RPS6 and p-4E-BP1 dramatically, which caused G1 cell cycle arrest and preventing reactivation of AKT and ERK (45). This evidence concerns the gene RPS6 and hereditary clear cell renal cell carcinoma.