TMPRSS2 and ischemic stroke: Serum angiotensin II level is also increased by the interaction of trans‐membrane serine protease 2 (TMPRSS2) with ACE2 receptors, resulting in a massive release of inflammatory cytokines together with monocyte‐derived macrophages and ultimately starts extrinsic coagulation pathway that results in fibrin elevation and blood clotting in ischemic stroke.61, 62